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0412U002902,
к.мед.н.
12-06-2012
o
Prevention and treatment of recurrent adhesive disease, complicated with acute intestinal obstruction.
Kotik Yuriy Mykolayovych,
popup.head SVansovych Vitaliy Evgenovych
popup.opponent Петрушенко Вікторія Вікторівна
popup.opponent Польовий Віктор Павлович
Об'єкт - хворі на спайкову хворобу (СХ) черевної порожнини, ускладнену гострою спайковою кишковою непрохідністю (СКН) та рецидивною СКН, що у минулому були оперовані на органах черевної порожнини, практично здорові особи; мета - покращити результати хірургічного лі-кування хворих із рецидивною СХ очеревини, ускладненою гострою кишковою непрохідністю, шляхом визначення діагностично-прогностичного критерію надмірного спайкоутворення та розробки методів комбінованого лікування із застосуванням синтетичних бар'єрних матеріалів і препара-тів ?-ліпоєвої кислоти та силімарину; методи - клініко-лабораторні, біохімічний, статистичний; результати - вперше комплексно визначені особли-вості змін у сироватці крові показників зв'язаного білком оксипроліну, глікозаміногліканів, активності еластази та показника N-ацетилнейраминової кислоти, що характеризують метаболізм сполучної тканини; проведено порівняльний аналіз змін показників активності колагеноутворення у хво-рих із гострою СКН, що у минулому перенесли хірургічні втручання на органах черевної порожнини та у хворих на СХ з рецидивом СКН; впе-рше запропоновано діагностико-прогностичний критерій, що характеризує високу активність метаболізму сполучної тканини у черевній поро-жнині, отже - високий ризик рецидиву СКН; доведено, що для профілактики рецидиву СКН найбільш ефективним є комбіноване застосування місцевих бар'єрних матеріалів із патогенетично спрямованою медикаментозною терапією; галузь - медицина.
2012-06-12
2020-04-04
Updated: 2026-01-13
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