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0415U001990,
к.мед.н.
29-04-2015
o
Pharmacological activity of new biologically active compound – cuprum-oxyethylidenbiphosphonogermanate
Tymchishin Oleg Lvovich,
popup.head Godovan Vladlena Volodymyrivna
popup.opponent Сотнікова Олена Петрівна
popup.opponent Бобирьов Віктор Миколайович
Дисертацію присвячено оцінці токсико-фармакологічного профілю нової біологічно активної речовини – купрум-оксіетилідендифосфонатогерманату (медгерму), виявленню її специфічної активності та основних механізмів дії. Вперше у гострому і хронічному експериментах встановлено його безпечність. Вперше визначено його дозозалежний депримуючий нейротропний вплив, анксіолітичну активність, відсутність гіпнотичної та міорелаксантної дії, а також анал-гетичний і протизапальний ефекти, підсилення детоксикуючої функції печінки. Вперше виявлено антагоністичну взаємодію з амфетаміном, синергізм з 5-окситриптофаном, що свідчить про вплив сполуки на моноаміноергічну центральну передачу. Вперше встановлено перевищуючий в 1,5-2,0 рази референс-препарат есенціале гепатозахисний ефект профілактично-лікувального введення медгерму дозою 0,4 мг/кг при гострому галактозаміновому гепатиті, який реалізувався переважно за рахунок активації антиоксидантної системи, а також пригнічення пероксидації ліпідів, вмісту загального холестерину крові та печінці. Отримані дані висвітлюють доцільність застосування медгерму як потенційного високоефективного і безпечного гепатопротекторного засобу.
2015-04-29
2020-04-03
Updated: 2025-12-07
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