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0416U000437,
к.мед.н.
03-02-2016
o
Clinico-functional features of cerebral hemodynamics in children with bronchial asthma and possibilities of their correction
Akulova Olena Yuriivna,
popup.head Nedelskaja Svitlana Nikolaevna
popup.opponent Овчаренко Леонід Сергійович
popup.opponent Беш Леся Василівна
Дисертація присвячена підвищенню ефективності лікування та удосконаленню ранньої діагностики цереброваскулярних порушень на підставі вивчення клініко-функціональних особливостей мозкової гемодинаміки (МГД) у дітей, хворих на бронхіальну астму (БА). Встановлено що, досягнення контролю над перебігом БА асоціюється із підвищенням в сироватці крові рівня вазоінтестинального пептиду та із зниженням рівня інтерлейкіну-5. Доведено, що у дітей, хворих на БА, спостерігаються порушення МГД у вигляді реґіонарної гіпоперфузії у вертебро-базилярній зоні мозку, явищ веностазу та ангіоспазму, зниження вазодилятаторного резерву та порушення механізмів ауторегуляції мозкового кровообігу. За даними кореляційного аналізу до чинників негативних змін МГД належать неконтрольованість перебігу, тривалість БА понад 5 років, гендерна приналежність хворих до чоловічої статі. Доведено негативний вплив порушень функції зовнішнього дихання, наявності системного запального процесу на показники МГД та когнітивні функції мозку дітей, хворих на БА. Встановлено, що позитивний вплив базисної терапії на МГД здійснюється за рахунок поліпшення показників венозного відтоку, зменшення проявів асиметрії кровотоку.
2016-02-03
2020-04-03
Updated: 2025-12-08
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