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0416U000730,
к.мед.н.
29-02-2016
o
Substantiation of prevention of major dental diseases in the chemical industry (clinical and experimental study)
Efremova Oksana Vasylivna,
popup.head Shnaider Stanislav Arkadievich
popup.opponent Ковач Ілона Василівна
popup.opponent Любченко Ольга Валеріївна
У обстежених робітників хімічного виробництва інтенсивність карієсу зубів у 20-40 років була в 2 рази вище, ускладнення - в 5,5 разів вище, а показники патологічного карману - в 26 разів вище, ніж в середньому по Україні. З ростом тривалості роботи в хімічному виробництві в першу чергу спостерігалося порушення структури кісткової тканини, а не її мінералізація. Крім того, у них спостерігалися 100 % порушення в генах другої фази детоксикації NAT2 (С481Т) і гена CTR (C1377T), що входить до генної мережі метаболізму кісткової тканини, які необхідно враховувати при розробці лікувально-профілактичних заходів. В експерименті на щурах в умовах надлишкового надходження перекисів ліпідів з їжею показана висока ефективність лікувально-профілактичного комплексу, що складався з адаптогенів, вітамінів, мінералів і високоякісного білка. Розроблений лікувально-профілактичний комплекс дозволив в основній групі робітників суттєво покращити показники стоматологічного статусу, нормалізувати біохімічні параметри ротової рідини, сироватки крові, зарядовий стан клітин букального епітелію, функціональний стан мікрокапілярного русла ясен і їх бар'єрний захист від мікробного фактора.
2016-02-29
2020-04-03
Updated: 2025-12-14
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