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0419U001443,
к.мед.н.
19-06-2019
o
Circadian rhythms of melatonin and galectin-3 production in patients with osteoarthritis: association with the disease course and the efficacy of treatment.
Humeniuk O V,
popup.head StanislavchukMykola Adamovych
popup.opponent ПроценкоГалина Олександрівна
popup.opponent Єрмолаєва Майя В'ячеславівна
Дисертація присвячена удосконаленню діагностики та лікування остеоартрозу (ОА) колінних суглобів шляхом виявлення особливостей циркадіанних ритмів продукції мелатоніну та галектину-3, їх зв'язку з перебігом захворювання, якістю життя та ефективністю фармакотерапії.У хворих на ОА знижується екскреція 6-сульфатоксимелатонінуз сечею (внічний період)та підвищується рівень галектину-3 в крові (без циркадіанного характеру), що достовірно асоціюється з посиленням больового синдрому, погіршенням фізичних функцій та якості життя, недостатньою клінічною відповіддю на стандартну фармакотерапію. Включення мелатоніну до схеми лікування ОАзменшує клінічні проявиі збільшує шанси досягнення WOMAC20.
2019-06-19
2020-04-03
Updated: 2025-12-08
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