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0419U001612,
к.мед.н.
27-09-2019
o
Endothelial, structural-functional and immune-inflammatory aspects of metabolic disorders in patients with arterial hypertension and type 2 diabetes mellitus and their correction
Chernatska Olha Mykolaivna,
popup.head Demikhova Nadiia Volodymyrivna
popup.opponent Оспанова Тетяна Сунгашівна
popup.opponent Опарін Олексій Анатолійович
Дисертаційна робота присвячена удосконаленню лікування шляхом розроблення нового диференційованого підходу до призначення антигіпертензивного препарату на підставі комплексного вивчення зв'язку між показниками функціонального стану ендотелію, нирок, серця, маркерами імунного запалення, урикемією, проатерогенною спрямованістю після визначення типів дисліпідемії, вмісту атерогенних та антиатерогенних ліпопротеїдів, оцінки геометрії лівого шлуночка. Доведена доцільність визначення співвідношення альбуміну до креатиніну в сечі; індексу маси міокарда лівого шлуночка як відношення ваги до квадрата зросту, зважаючи на наявність супутнього ожиріння чи надмірної ваги у хворих на артеріальну гіпертензію та цукровий діабет 2-го типу. В якості маркеру порушення функції ендотелію доцільним є визначення вмісту ендотеліну-1, імунозапального статусу - фактора некрозу пухлин-?. Концентрація розчинної форми молекули адгезії судинного ендотелію 1-го типу є показником функції ендотелію і вираженості імунозапальних реакцій. Обґрунтовано новий диференційований підхід до призначення телмісартану, що полягає у призначенні 40 мг/добу препарату, якщо вміст ендотеліну-1 є меншим за 10 пг/мл, та 80 мг/добу, якщо вміст ендотеліну-1 перевищує 10 пг/мл.
2019-09-27
2020-04-03
Updated: 2025-12-14
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