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0419U003281,
Кандидат фармацевтичних наук
24-06-2019
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Pharmacоgnоstic study оf garden burnet (Sanguisоrba оfficinalis L.), cultivated in Ukraine
Kudria Viktoriia V.,
popup.head Marchyshyn Svitlana М.
popup.opponent Khvorost Olga P.
popup.opponent Darmohray Roman Ye.
Дисертаційна робота присвячена комплексному фармакогностичному дослідженню культивованого родовика лікарського (Sanguisоrba оfficinalis L.). Методом спектрофотометрії у досліджуваних видах сировини родовика лікарського визначено кількісний вміст суми кислот гідроксикоричних, суми флавоноїдів, суми поліфенолів, танінів, кислоти аскорбінової. Методом ВЕРХ встановлено компонентний склад амінокислот та фенольних сполук в сировині: компоненти дубильних речовин, кислоти гідроксикоричні, флавоноїди та кумарини. Методом ААС встановлено наявність і визначено кількісний вміст макро- і мікроелементів.. Встановлено основні діагностичні морфолого-анатомічні ознаки досліджуваних об’єктів, визначено оптимальні технологічні параметри одержання субстанцій з сировини родовика лікарського. З трави та кореневищ і коренів родовика лікарського одержано сухі екстракти. Встановлено протизапальні та антимікробні властивості сухого екстракту трави, протизапальну, кровоспинну та антимікробну дію сухого екстракту кореневищ і коренів. Визначено їх гостру токсичність. Результати комплексного фармакогностичного аналізу підземних органів культивованого в Україні родовика лікарського направлено на розгляд у ДП «Український науковий фармакопейний центр якості лікарських засобів" для розробки національної частини монографії ДФУ 2.0.
2019-06-24
2020-04-03
Updated: 2025-12-09
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