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0419U003374,
Кандидат фармацевтичних наук
26-06-2019
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Development of composition, technology and research of tablet formulations of Pyrola rotundifolia extract
Darzuli Natalia P.,
popup.head Hroshovyi Taras A.
popup.opponent Davtian Lena L.
popup.opponent Dmitrievskiy Dmitro I.
Об’єкти – листя грушанки круглолистої, сухий екстракт грушанки круглолистої, допоміжні речовини, маси для таблетування та таблетки на їх основі; мета – обґрунтування складу, розробка технології та дослідження таблеток на основі сухого екстракту грушанки круглолистої з нефропротекторною активністю при захворюваннях органів сечовивідної системи; методи – загальнонаукові, органолептичні, фізико-хімічні, фармако-технологічні, мікробіологічні, біологічні, математично-статистичні; новизна – здійснено фармацевтичну розробку лікарського засобу у формі таблеток на основі стандартизованого екстракту листя грушанки круглолистої, який пропонується застосовувати для лікування захворювань сечовивідних шляхів; результати – розроблено технологію сухого фітоекстракту, проведено його фізико-хімічні та технологічні дослідження, використовуючи методи математичного планування експерименту, теоретично обґрунтовано і експериментально підтверджено оптимальний склад і технологію таблеток на основі стандартизованого сухого екстракту листя грушанки круглолистої, опрацьовано та обґрунтовано методики якісного та кількісного аналізу розроблених таблеток, встановлено термін їх придатності та умови зберігання, вивчено фармакологічні властивості запропонованих таблеток, проведено апробацію технології та методик контролю якості сухого фітоекстракту та таблеток на їх основі в умовах промислового виробництва; впроваджено – у науковий процес вищих навчальних закладів, ТОВ «Тернофарм»; галузь – фармація.
2019-06-26
2020-04-03
Updated: 2025-12-14
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