Registration Number
2121U010411, Article
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Текст
Title
Personalized diet improve intestinal microbiota and metabolism of obese rats (AI translated)
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Баті Вікторія Віталіївна
Мелешко Тамара Вадимівна
Паллаг Олександра Володимирівна
Заячук Ілля Петрович
Бойко Надія Володимирівна
Bati Viktoriya Vitaliivna
Meleshko Tamara Vadymivna
Pallah Oleksandra Volodymyrivna
Zayachuk Illya Petrovych
Boiko Nadiya Volodymyrivna
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01-01-2021
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/jspui/handle/lib/50702
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National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
Description
Recent research on human microbiome provide opportunities to develop functional foods of new generation that can regulate intestinal microbiota and the biochemical status of the individual. The aim of the study was to determine the effect of individually designed nutrition on the intestinal microbiota and metabolic parameters of rats. Outbred laboratory rats with obesity were randomly divided into 9 groups (n = 12) depending on the type of food ingredients taken orally for three months. The ratio of the intestinal commensal microorganisms main groups, as well as the lipid profile and the content of glucose, urea, calcium in the serum of animals were determined. It was shown that cholesterol level in the serum was reduced in experimental groups after consumption of lactobacilli suspension, blueberry juice, fermented milk drink based on lactobacilli, fermented milk drink with blueberry juice, sauerkraut. In most cases, the gut microbiome of experimental animals was characterized by a consistently high level of lacto and other beneficial bacteria and decreased amount of opportunistic microorganisms at the end of the experiment compared with animals in the control group. Based on the obtained data, we first proposed the principles of creating functional products by synergistically combining components of edible plants that act as prebiotics and microorganisms that act as probiotics for personalized use, targeted correction of intestinal microbiome and prevention of noncommunicable diseases.
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2026-06-13
