Registration Number
2122U007992, Article
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Текст
Title
Morphological peculiarities of the pancreas of male rats after prolonged administration of monosodium glutamate during the recovery period (AI translated)
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Lytvak Yulia V.
Harapko Tetiana
Lytvak Vasil
Foros Anatolii I.
Литвак Юлія Володимирівна
Гарапко Тетяна Василівна
Литвак Василь Васильович
Форос Анатолій Ілліч
Lytvak Yulia V.
Harapko Tetiana
Lytvak Vasil
Foros Anatolii I.
Lytvak Yuliya Volodymyrivna
Harapko Tetyana Vasylivna
Lytvak Vasyl Vasylovych
Foros Anatolii Illich
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01-01-2022
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/jspui/handle/lib/59301
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Aluna Publishing
Description
The aim: To study changes in the exocrine and endocrine parts of the pancreas of rats after abolition of monosodium glutamate (MSG) administered in the diet.
Materials and methods: White male laboratory rats with a baseline weight of 120 ± 5 g were randomized into 3 groups: 1 – control, 2 – animals with daily feeding of 70 mg/
kg MSG for 8 weeks, 3 – abolition of MSG with transfer of animals to a standard diet and pancreatic examination after 8 weeks. We used histological studies with morphometric
analysis and statistical processing of acini and acinar cell areas, Langerhans islets, connective tissue (according to Stolte M.) and adipose tissue. Preparations of pancreas were
stained with hematoxylin and eosin and azan.
Results: The animals of groups 2 and 3 showed atrophic, degenerative and inflammatory disturbances in the exocrine and endocrine parts of the pancreas, which worsened
after 8 weeks of MSG withdrawal (3 rd group). In the preparations, the Langerhans islets were of different shapes and sizes. Small islets predominated, as well as islets with low
density of α- and β-cells, different capillary filling with blood and overgrowth of connective tissue in the capillary areas. The acinar cells and acini were reduced, and degenerative
abnormalities were detected in the structures.
Conclusions: After daily administration of 70 mg/kg MSG for 8 weeks, atrophic and degenerative changes in the exocrine and endocrine parts of the pancreas were revealed.
No recovery of pancreatic structures was observed 8 weeks after MSG withdrawal.
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2026-06-13
