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Information × Registration Number 2123U001849, Article popup.category Стаття Title Platelets amino acids profile and cardiometabolic risk factors in patients with coronary artery disease and atrial fibrillation (AI translated) popup.author Melnychuk I.Melnychuk I. popup.publication 01-01-2023 popup.source_user Національний медичний університет імені О. О. Богомольця popup.source http://ir.librarynmu.com/handle/123456789/14738 popup.publisher Description To found out connections between platelets amino acids profile and cardiometabolic risk factors in coronary artery disease patients with atrial fibrillation. 300 patients were divided into 3 groups: first (I) – 149 patients with coronary artery disease and without arrhythmias, second (II) – 123 patients with coronary artery disease and atrial fibrillation paroxysm and 28 patients in control group. In II group in comparison with I group were checked (P<0.05): increasing isoleucine (10.73 %), leucine (12.63 %) and decreasing threonine (23.05 %), serine (5.06 %), glycine (32.21 %), valine (30.83 %) levels in platelets amino acids profile; elevation of apolipoprotein B (29.91 %), C-reactive protein (40.93 %), interleucine-6 (22.93 %), trimethylamine (16.13 %) and trimethylamine-N-oxide (57.54 %) levels and fall of trimethylamine / trimethylamine-N-oxide ratio (26.16 %). Majority of correlations were found between glycine (total number = 12), threonine (total number = 6), glutamate (total number = 6), valine (total number = 6) and cardiometabolic risk factors. Platelets glycine correlated with age (r=-0.305), body mass index (r=-0.351), total cholesterol (r=-0.304), low density lipoprotein (r=-0.348), apolipoprotein A1 (r=0.373), apolipoprotein B (r=-0.347), interleucine-6 (r=-0.315), trimethylamine-N-oxide (r=-0.654), trimethylamine / trimethylamine-N-oxide ratio (r=0.688), prothrombin index (r=0.317), activated partial thromboplastin time (r=-0.365) and fibrinogen (r=-0.396), P<0.05. popup.nrat_date 2026-04-22 Close