Registration Number
2123U012601, Article
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Текст
Title
A study of the influence of juvenile adjuvant arthritis on dental hard tissue condition in experimental animals (AI translated)
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Kulygina Valentyna M.
Pylypiuk Olha Yu.
Turchyn Iurii V.
Gadzhula Nataliia G.
Shinkaruk-Dykovytska Mariia M.
Povsheniuk Anastasiia V.
Kovalchuk Lina O.
Kulygina Valentyna M.
Pylypiuk Olha Yu.
Turchyn Iurii V.
Gadzhula Nataliia G.
Shinkaruk-Dykovytska Mariia M.
Povsheniuk Anastasiia V.
Kovalchuk Lina O.
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01-11-2023
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/jspui/handle/lib/59826
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Wiadomości Lekarskie Medical Advances
Description
ABSTRACT
The aim: To studythe intensity and depth of carious tooth lesions in rats with experimental juvenile adjuvant-induced arthritis.
Materials and methods: An experimental study on a model of juvenile adjuvant arthritis (JAA) in 10 one-month-old rats induced by method of A.M. Bendele
was carried out. 10 rats of the same age were intact. Injection of adjutant in rats of experimental group led to the development of acute local reaction and then
caused generalized joint reaction of autoimmune origin. The performed basic therapy of JAA promoted transition of acute autoimmune process to chronic. Rats
were withdrawn from the experiment in 58 days and the dental-jaw blocks were made, in which the intensity and depth of carious lesions of the masticatory
group of teeth were determined.
Results: The course of JAA was accompanied by the development of dental caries in 100% of experimental animals. It was found that the intensity of carious
teeth lesions in terms of the number of carious teeth and cavities is probably higher than in intact rats (respectively 4.3 ± 0.3 vs. 2.2 ± 0.6 and 4.5 ± 0.3 vs.
2.3 ± 0.7, p <0.001). In rats with JAA, mostly middle and deep carious cavities were revealed, at the same time in intact rats – superficial and middle carious
cavities were observed.
Conclusions: It has been established that adjuvant arthritis is accompanied by 100% prevalence of dental caries, high intensity of carious process, presence
of middle and deep carious cavities, that confirm the negative influence of autoimmune disease on the condition of the hard tooth tissues.
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2026-06-13
