Search academic texts

Information × Registration Number 2124U000944, Article popup.category Стаття Title Copper Nanoparticle Loaded Electrospun Patches for Infected Wound Treatment: From Development to In-Vivo Application (AI translated) popup.author Буцик Анна СергіївнаВарава Юлія ВалентинівнаМоскаленко Роман АндрійовичГусак Євгенія ВолодимирівнаПіддубний Артем МихайловичДенисенко Анастасія ПетрівнаКорнієнко Валерія ОлегівнаПогорєлов Максим ВолодимировичКорнієнко Вікторія ВолодимирівнаButsyk Anna SerhiivnaVarava Yuliia ValentynivnaMoskalenko Roman AndriiovychHusak Yevheniia VolodymyrivnaPiddubnyi Artem MykhailovychDenysenko Anastasiia PetrivnaKorniienko Valeriia OlegivnaRamanaviciute A.Banasiuk R.Pohorielov Maksym VolodymyrovychRamanavicius A.Korniienko Viktoriia Volodymyrivna popup.publication 01-01-2024 popup.source_user Сумський державний університет popup.source https://essuir.sumdu.edu.ua/handle/123456789/98648 popup.publisher Sumy State University Description This study investigates the development and application of electrospun wound dressings based on polylactic acid (PLA) nanofibers, chitosan, and copper nanoparticles (CuNPs) for the treatment of purulent skin wounds. The materials were evaluated for their structural, antibacterial, and wound healing properties using an animal model. PLA/Ch-CuNPs demonstrated the most significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, surpassing the other tested materials. The integration of CuNPs into the nanofiber matrices not only enhanced the antimicrobial efficacy but also maintained the structural integrity and biocompatibility of the dressings. In vivo experiments using a rat model showed that PLA/Ch-CuNPs facilitated faster wound healing with reduced exudative and inflammatory responses compared to PLA alone or PLACuNPs. Histological and immunohistochemical assessments revealed that the combination of PLA, chitosan, and CuNPs mitigated the inflammatory processes and promoted tissue regeneration more effectively. However, this study identified potential toxicity related to copper ions, emphasizing the need for careful optimization of CuNP concentrations. These findings suggest that PLA/Ch-CuNPs could serve as a potent, cost-effective wound dressing with broad-spectrum antibacterial properties, addressing the challenge of antibiotic-resistant infections and enhancing wound healing outcomes. popup.nrat_date 2026-04-17 Close