Registration Number
2124U012832, Article
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Текст
Title
Features of exocrine pancreatic insufficiency in patients with non-alcoholic fatty liver disease in combination with type 2 diabetes and COVID-19 (AI translated)
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Sirchak Yelyzaveta S.
Kalytych Vasyl V.
Dobryanska (Opalenyk) Erica S.
Mihlyas Volodimir G.
Kohutych Ivan I.
Brych Valeriya V.
Опаленик Еріка Степанівна
Сірчак Єлизавета Степанівна
Мігляс Володимир Георгійович
Ivachevskyi Mykhailo M.
Івачевський Михайло Михайлович
Брич Валерія Володимирівна
Sirchak Yelyzaveta S.
Kalytych Vasyl V.
Dobryanska (Opalenyk) Erica S.
Mihlyas Volodimir G.
Kohutych Ivan I.
Brych Valeriya V.
Opalenyk Erika Stepanivna
Sirchak Yelyzaveta Stepanivna
Mihlyas Volodymyr Heorhiiovych
Ivachevskyi Mykhailo M.
Ivachevskyi Mykhailo Mykhailovych
Brych Valeriya Volodymyrivna
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01-01-2024
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/jspui/handle/lib/63028
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Description
Aim: The aim of the research was to study the features of pancreatic exocrine insufficiency (EPI) in patients with nonalcoholic fatty liver disease (NAFLD) and
type 2 diabetes mellitus (DM) at COVID-19.
Materials and Methods: 72 patients with NAFLD and COVID-19 were examined. The patients have been divided into two groups: group 1 included 42
patients with NAFLD and insulin resistance (IR); group 2 consisted of 30 patients with NAFLD in the combination with type 2 DM. EPI was detected by 13С-mixed
triglyceride breath test (13С-MTBT) in all the patients.
Results: The result of 13С-MTBT indicates EPI in the examined subjects of the 2 group. A significant decrease in the maximum concentration of 13СО2 between
150 and 210 min was also diagnosed in group 1 patients. research (up to 8.2 ± 0.9% – p < 0.05), however, the total concentration of 13СО2 at the end of 360
min. the study reached only 27.7 ± 1.1% (p < 0.05).
Conclusions: Based on the results of laboratory-instrumental methods of research, patients with NAFLD and type 2 diabetes with COVID-19 were diagnosed
with severe EPI. The results of 13С-MTBT in NAFLD and IR with COVID-19 indicate a decrease in the functional reserves of the pancreas and the formation of its EPI.
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2026-06-13
