Registration Number
2124U012899, Article
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Текст
Title
Evaluation of the treatment effectiveness in children with coronavirus infection (AI translated)
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Horlenko Olesya M.
Hechko Khrystyna A.
Prylypko Lyubomyra B.
Derbak Maria A.
Hecko Mykhaylo
Horlenko Fedir V.
Горленко Олеся Михайлівна
Гечко Михайло Михайлович
Гечко Христина Андріївна
Прилипко Любомира Богданівна
Дербак Марія Антонівна
Horlenko Olesya M.
Hechko Khrystyna A.
Prylypko Lyubomyra B.
Derbak Maria A.
Hecko Mykhaylo
Horlenko Fedir V.
Horlenko Olesya Mykhailivna
Hechko Mykhailo Mykhailovych
Hechko Khrystyna Andriivna
Prylypko Liubomyra Bohdanivna
Derbak Mariya Antonivna
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01-01-2024
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/jspui/handle/lib/68032
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Description
Aim: To study and analyze the treatment effectiveness in children with identified Coronavirus infection.
Materials and Methods: included the treatment and analysis of the study results of of children (n=68, aged 14.36±3.62 years), with confirmed Coronavirus
infection, who were observed in outpatient settings and in comparison with the control group (n=28).
Results: Positive dynamics after treatment were observed in all parameters of the CBC (р4<0.01-0.03), except in the level of Platelets (р1=0.65; р2=0.3,
р3=0.21, р4=0.59) and Eosinophils (p1=0.40, p4=0.06). The levels of vitamin D3 and Zn were below the reference limit at the initial stage of the study and
reached the physiological norms (р2=0.14,р2=0.09, respectively). Increasings of Ig M levels in 2.7 times, Ig E - in 10.6 and Ig A -in 3.3 were observed on the
starting stage and have positive trend with the normalization of the levels after 6 months, which was confirmed by statistical significance (р4=0 ,06, p4=0.10,
p4=0.54, respectively).
Conclusions: A level decrease in the the obtained indicators was observed after treatment in the next: IL-1 in 39.3 times, IL-4 in 6.6 times, IL-6 in 14.3 times,
TNF-αin 49.2 times, γ-IFN in 11.2 times, D-dimer -in 14.1 times, Neopterin -in 10.1 times, CRP- in 5.4 times and Fibrinogen -1.9 times. The level of Anti IgGSARS-
CoV-2S1-RBD exceeded the permissible level in 13.8 times. The levels of Adiponectin, Leptin and C-peptide significantly have decreased after treatment
(p1<0.01) and after 6 months.
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2026-06-13
