Registration Number
2125U009175, Article
popup.category
Текст
Title
Clinical manifestation, laboratory and instrumental characteristics of infants born to mothers with complicated anamnesis (AI translated)
popup.author
Horlenko Olesya M.
Kossey Gabriella B.
Chuhran Yurij Yu
Derbak Mariya A.
Symulyk Volodymyr D.
Pushkash Lybov Yu.
Ivano Viktoriia V.
Іваньо Вікторія Володимирівна
Чухран Юрій Юрійович
Горленко Олеся Михайлівна
Коссей Габріелла Барнабашівна
Дербак Марія Антонівна
Пушкаш Любов Юріївна
Horlenko Olesya M.
Kossey Gabriella B.
Chuhran Yurij Yu
Derbak Mariya A.
Symulyk Volodymyr D.
Pushkash Lybov Yu.
Ivano Viktoriia V.
Ivano Viktoriya Volodymyrivna
Chukhran Yurii Yuriiovych
Horlenko Olesya Mykhailivna
Kossei Habriella Barnabashivna
Derbak Mariya Antonivna
Pushkash Liubov Yuriivna
popup.publication
01-01-2025
popup.source_user
Ужгородський національний університет
popup.source
https://dspace.uzhnu.edu.ua/handle/lib/79194
popup.publisher
Description
Aim: To improve early diagnosis by analyzing the pathological pattern of «mother-newborn» in newborns.
Materials and Methods: The study group included newborns with a diagnosis of “Infection specific to the perinatal period, unspecified” (P39,9, n=64), born
to mothers (age 31,31 ± 2,08 years) with a complicated diagnosis and a control group (n=31) of infants.
Results: Clinical manifestations in newborns mainly included involvement of the central nervous system (57,8%), cardiovascular system (12,0%), congenital
heart defects (2,8%), jaundice (11,0%), hepatosplenomegaly (5,2%), exanthema (9,0%), hypothermia (70,6%). Markers of inflammatory response confirmed
an increase in the level of IL-1, a significant increase in IL-6 levels, the level of IL-8 in the studied contingent also significantly differs from the data of the control
group, the level %-IFN also exceeded the reference values by 2,4 times. Hypoxic-ischemic encephalopathy was detected in 63 infants (57,8%) and intracranial
hemorrhage was diagnosed in 25 (22,9%) infants.
Conclusions: The values of cytokine profile parameters (IL-1, IL-6, IL-8, IL-10) on the first day of life varied within the reference values, but with significant
differences from the values of the control group, which were 9,24; 20; 11 times, respectively. The levels of inflammatory mediators (%-IFN, procalcitonin, neopterin,
TNF-α, Pg E2) significantly differed from the data of the control group and exceeded the upper limit of reference values by 2,4; 40; 8,9; 25; 3,5 times, respectively.
popup.nrat_date
2026-06-13
