Registration Number
2125U009209, Article
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Текст
Title
Peculiarities of changes in the level of vitamins B in patients with gastroesophageal reflux disease metabolic-associated fatty liver disease (AI translated)
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Yelyzaveta S. Sirchak
Bohdana V. Bezushko
Mykhailo M. Havrylec
Viktoria M. Hadzheha
Habriella E. Reyti
Yurii P. Balazh
Oleksandr M. Kochmar
Yelyzaveta S. Sirchak
Bohdana V. Bezushko
Mykhailo M. Havrylec
Viktoria M. Hadzheha
Habriella E. Reyti
Yurii P. Balazh
Oleksandr M. Kochmar
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01-08-2025
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/handle/lib/79260
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Aluna Publishing
Description
ABSTRACT
Aim: To determine the peculiarities of changes in the levels of B vitamins and their dependence on body mass index (BMI) in patients with GERD and metabolic
dysfunction-associated fatty liver disease (MDAFLD).
Materials and Methods: 112 patients with GERD were examined. Patients were divided into two groups. Group 1 included 50 patients with GERD, and group
2 consisted of 62 patients with GERD in combination with MDAFLD. The level of homocysteine and B vitamins in the blood serum was determined.
Results: At patients group 1 were diagnosed the decreased levels of B6 and B12 in blood serum against a background of a slight increase in homocysteine
levels in blood serum (up to 17.9±0.7 umol/l – p<0.05). In patients in group 2, a significant decrease in all B vitamins examined in the blood serum was found,
accompanied by a significant increase in homocysteine levels (2.4 times – p<0.01).
Conclusions: In the vast majority of patients with GERD and MDAFLD, an increase in BMI was found, namely, overweight in 25.8% (p < 0.01) of patients and
grade I obesity (in 37.1% of patients – p < 0.001). In patients with GERD and MDAFLD, a significant decrease in serum levels of B vitamins (B1, B3, B6, B9,
B12) was found, which correlates negatively with overweight and obesity in these patients.
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2026-06-13
