Registration Number
2125U009351, Article
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Текст
Title
Prevalence of gastroduodenal disorders in patients with thyroid dysfunction (AI translated)
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Derbak Mariya A.
Timashev Volodymyr V.
Hanych Oksana T.
Svistak Vasilina V.
Dankanych Yevheniia О.
Дербак Марія Антонівна
Ганич Оксана Тарасівна
Свистак Василина Василівна
Данканич Євгенія Еміліянівна
Derbak Mariya A.
Timashev Volodymyr V.
Hanych Oksana T.
Svistak Vasilina V.
Dankanych Yevheniia O.
Derbak Mariya Antonivna
Hanych Oksana Tarasivna
Svystak Vasylyna Vasylivna
Dankanych Yevheniya Emiliyanivna
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01-01-2025
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Ужгородський національний університет
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https://dspace.uzhnu.edu.ua/handle/lib/85426
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Zaslavsky Publishing House
Description
Background. The functional state of the digestive system depends on complex neurohumoral regulatory mechanisms. Given the ability of thyroid hormones to influence gastrointestinal homeostasis, it is essential to assess the functional state of the thyroid gland and its role in the development of various gastrointestinal diseases. The aim of the research was to investigate the prevalence of major digestive system disorders (gastroesophageal reflux disease, peptic ulcer disease, gastritis, and functional dyspepsia) in patients with impaired thyroid function. Materials and methods. The study included 294 patients with thyroid dysfunction. Among them, drug-induced euthyroidism maintained with levothyroxine therapy was observed in 196 patients (66.7 %). In 24 individuals (8.2 %), incomplete compensation of thyroid hypofunction with levothyroxine was noted, since the mean thyroid-stimulating hormone (TSH) level was 5.42 ± 0.55 mIU/mL and clinical symptoms were present. Hypothyroidism with TSH levels ranging from 6.0 to 10.0 mIU/mL was found in 35 patients (11.9 %), while TSH levels > 10.0 mIU/mL were registered in 18 (6.1 %). Hyperthyroidism was observed in 21 out of 294 patients (7.1 %). Elevated antithyroid antibody levels (more than twofold above the reference range) were detected in 70 patients (23.8 %). Results. Gastroenterological symptoms among individuals with thyroid dysfunction were identified in 81.6 % (240/294) of patients and were characterized by heartburn in 66.3 % (195/294), a sensation of heaviness in the epigastric region in 80.9 % (238/294), loss of appetite in 21.4 % (63/294), belching in 31.9 % (94/294), nausea in 27.9 % (82/294), and vomiting in 11.9 % (35/294). Flatulence was reported by 13.6 % (40/294), constipation by 14.3 % (42/294), pain along the esophagus by 11.9 % (35/294), epigastric pain by 21.4 % (63/294), and palpitations by 8.2 % (24/294) people. Helicobacter pylori infection was detected in 59.5 % (175/294) of patients. Gastroesophageal reflux disease was diagnosed in 36.7 % (108/294), functional dyspepsia in 31.3 % (92/294), chronic gastritis in 32.6 % (96/294), and peptic ulcer disease in 12.9 % (38/294) of patients. Conclusions. It was found that patients with hypothyroidism more frequently presented with gastroesophageal reflux disease and functional dyspepsia (16.7 and 13.5 %, respectively), those with drug-induced euthyroidism were more likely to develop functional dyspepsia (23.0 %), while patients with hyperthyroidism more commonly had peptic ulcer disease (15.7 %). Further studies should evaluate the relationships between thyroid hormone, gastrin, and pepsinogen levels, as well as clarify the influence of thyroid hormones on esophageal motility. © 2025, Zaslavsky Publishing House. All rights reserved.
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2026-06-13
