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Information × Registration Number 0120U103332, ( 0221U102450  0222U000734  ) R & D request Title Development of the technology for obtaining of recombinant bioconjugates for regenerative medicine and study of their properties Head Kordyum Vitaliy A., Доктор біологічних наук Registration Date 10-07-2020 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description1 The project is aimed at the development of a laboratory technology for obtaining of recombinant bioconjugates based on stromal cell factor 1ɑ (SDF-1ɑ) or an analogue of a soluble form of heparin-binding growth factor similar to human epidermal growth factor (sHB-EGF) with bioaffinity labels (CBD, His-tag, etc.); the development of carriers for bioconjugates based on biocompatible polysaccharides chitosan and heparin, and the study of the functional properties of the obtained bioactive compounds. The project includes development of plasmid constructs containing fusion protein genes, obtaining of overproducers of recombinant bioconjugates, development of effective and technological methods for obtaining preparative quantities of functionally active protein products, their immobilization on polymeric media, study of biological activity of the proteins, and obtaining of prototypes of preparations based of the developed bioconjugates, which can be applied in regenerative medicine popup.nrat_date 2024-12-10 Close