Registration Number
0123U103623,
(
0224U031896
)
R & D request
Title
Design and synthesis of condensed heterocyclic systems based on 1,4-quinones, quinoxalines and 1,3,5-triazines
Head
Polovkovych Sviatoslav V., Доктор хімічних наук
Registration Date
05-09-2023
Organization
Polovkovych Sviatoslav V.
popup.description1
The purpose of this research is the molecular design and development of synthetic methods by using nucleophilic substitution, cyclocondensation and cycloaddition reactions to obtain new condensed and non-condensed carbo- and heterocyclic derivatives of quinones, quinoxalines and 1,3,5-triazines, followed by their chemical modification and search among them effective biologically active compounds. The development of new synthetic approaches with the use of multicomponent, single-reactor, tandem, and domino variants of chemical transformations in the synthesis of complex polycyclic heterocyclic compounds is expected. It is planned to develop methodologies for the design and synthesis of combinatorial libraries of compounds that can be used to create drugs and to obtain new materials. Development of methods for the synthesis of new exofunctionalized derivatives of 2,3-dichloro-naphthalene-1,4-dione, which are based on the reaction of nucleophilic substitution is planned. The molecular design of structural blocks and the synthesis of annelated polyheterocyclic derivatives of naphthalene-1,4-dione based on them using the cyclocondensation reaction are expected. To establish the regioselective character of 1,3-dipolar cycloaddition and Diels-Alder reaction of a series of dienes at the 2nd or 3rd position of 5-R-naphthalene-1,4-diones will be studied. Research on new transformations using naphthalene-1,4-diones and their derivatives as synthetic analogues of electron-deficient alkenes in the [3+2] cycloaddition reaction will gain further development. It is planned to carry out virtual and in vitro screening of antitumor, antithrombotic activity and antimicrobial action, to identify lead compounds and put forward hypotheses regarding possible mechanisms of their action.
popup.nrat_date
2024-12-09
