Registration Number
0211U006830,
0110U001418
, R & D reports
Title
Correlatin of the immunogenicity and peculiarites of nucleoproteidic structure of actual influenza vaccines
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Head
Volyanskiy Andriy Yuriyovich,
Registration Date
12-04-2011
Organization
The Mechnikov Research Institute of microbiology and immunology at Kharciv
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Immunogenicity and the basic characteristics of proteinous components of actual influenza virus vaccines were investigated. The bond between proteinous composition and immunogenicity of modern seasonal inactivative split- and subisolated threevalent vaccines was revealed. General proteinous quantity and proteinous components number of threevalent subisolated Influvac and Grippol vaccines were essentially less then threevalent split-vaccine Vaxigrip. Seroconversion indexes of split-vaccine Vaxigrip reliably exceed analogous parametres of subisolated Influvac vaccine was showed. Subisolated adjuvantic Grippol vaccine's immunogenicity approach to such index of split-vaccine Influvac, for that it exceed Vaxigrip immunogenicity in the enumeration to the mass unit of virus proteine mixture.All parametres of adjuvant subisolated vaccine Monogrippol reliably exceed unadjuvant split-vaccine Panenza and ajuvant subisolated vaccine Monogrippol Neo among anti-pandemic monovaccines, which were studied.Practical recomendations for the improvement of influenza virus vaccines elaboration with aim of effectiveness increase, reactogenity and cost prise reduction were let.
Product Description
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Ігумнова Н.І.
Богатир Н.І.
Волянський А.Ю.
Кашпур Н.В.
Кучма І.Ю.
Мартинов А.В.
Перемот С.Д.
Романова О.А.
Сидоренко Т.А.
Симиренко Л.Л.
Смілянська М.В.
Чернова Л.В.
Юхименко В.І.
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2020-04-02
