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Information × Registration Number 0215U001806, 0111U009944 , R & D reports Title Developing new ways for obtaining geterokondensed systems and directed synthesis of anti-tumor compounds popup.stage_title Head Popov Anatoly Fedorovich, Доктор хімічних наук Registration Date 20-05-2015 Organization LM.Litvinenko Institute of Physical Organic and Coal Chemistry popup.description2 The object of study - 1,2-diazepine and 1,2-diazotsiny fused with an aryl or hetaryl moiety containing heteroatoms of oxygen, nitrogen or sulfur. Purpose - to develop methods for the synthesis and modification of structures geterokondensirovannyh 2,3-benzodiazepines, benzofurodiazepines, benzotienodiazepines and indolodiazepines using annulation reactions of heterocycles to diazepine nucleus, as well as reactions Bischler Napiralskogo-Pictet-Spengler reactions.. Metods of research - methods of organic synthesis, mass- and NMR - spectroscopy, X-ray analysis. The methods of synthesis of benzofurodiazepines, benzothienodiazepines and indolodiazepines by ring formation derivative of 2-aroylbenzothieno -3-, 2- aroylbenzofuro-3- and 2- aroylindolo- 3-acetic acids by hydrazine hydrate in various experimental conditions are developed. In contrast to 2-aroylbenzene derivative 2-acetylbenzothieno-3-acetyc acid react with hydrazine with reception hydrozones, which in conditions of acid catalysis interacted to 2-amino-1-methylbenzothieno[2,3-с]pyridines. The chemical updating of structure 3,5-dihydro-4H-[1]benzofuro [2,3-d][1,2]diazepin-4-оne and 3,5 dihydro-4H-[1] benzofuro[2,3-d][1,2]diazepin-4-thione is carried out. A number new derivative of 3-N-substituted benzofuro[2,3-d][1,2]diazepines are obtained. The direct conversion benzofuro[2,3-d][1,2]diazepin-4-ones is carried out in benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines by method of silylation-amination. The new method of synthesis unknown 9-(4-chlorophenyl)-3-methyl-6-phenyl-6,12-dihydro-7H-benzofuro[3,2-e][1,2,4]triazolo[4,3-b][1,2]diazepines based on interaction 4-aminotriazole with aromatic aldehydes in conditions of Pictet-Spengler reaction is developed. The results of work can be utilised in organic chemistry, for synthesis of biologically active compounds, for creation of new drugs Product Description popup.authors Євтушенко В.І. Єресько О.Б. Абрамянц М.Г. Асташкіна Н.В. Білобров В.М. Богдан Н.М. Богза С.Л. Бородкін Я.С. Гресько С.В. Дмитрук О.Ф. Зінченко С.Ю. Завязкіна Т.І. Заречна О.М. Земська Є.А. Кібальний О.В. Каніболоцький О.Л. Коваль Т.С. Ломов Д.О. Матвєєва Д.І. Михайлова В.М. Панкіна О.Ю. Пашкевич В.П. Пендюх В.В. Пилипенко Л.М. Попов В.Ю. Попов О.Ю. Романцевич А.М. Сидякін Д.В. Сизоненко О.С. Суйков С.Ю. Сухарева В.В. Суховій О.В. Толкунов А.С. Толкунов В.С. Толкунов С.В. Тюріна Т.Г. Хабаров К.М. Харанеко О.І. Хижан О.І. Хомутова К.В. Цикало Л.І. Яковлева Г.В. popup.nrat_date 2020-04-02 Close