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Information × Registration Number 0217U001172, 0116U002079 , R & D reports Title Studing of antiviral properties of nitrogen-containing heterocyclic compounds which belong to a number of symmetric and asymmetric triazines popup.stage_title Head Derevianko Stanislav, Registration Date 26-01-2017 Organization Institute of agricultural microbiology and agro-industrial production of National academy of agrarian sciences of Ukraine popup.description2 Scientific report: 26 sec., 3 tab., 35 sources. The object of research - cytotoxic action in cultures of cells and antiviral activity of nitrogen-containing heterocyclic compounds in rows of symmetrical and asymmetrical triazine. The purpose of research - the search for new antiviral compounds for development on the basis of new antiviral drugs. Research Methods - virological and statistics. A patent search and analysis of current published data on the impact of heterocyclic compounds on the reproductive activity of viruses. As a result of the experiments found that the optimal solvent for nitrogen-containing heterocyclic compounds in rows of symmetrical and asymmetrical triazine is dimethyl sulfoxide. Maksymalno permissible concentration of substances for 1411, 3816, 20963 of 100 mg / cm3, agents 5681 and 2993 - 25 g / cm3, and substance 0506, 055, 22730, 11881, were more toxic to the cell culture SNEV. 056 The substance is not toxic to cell cultures even at a dose of 400 mg / cm3. The most pronounced antiviral activity to the strain of Porcine Teschovirus serotype 1 Dnipro-34 chemicals have 056, 20963, 1411, which prompted widespread reduction in viral titer of 2.8; 2,74 and 2,62 lg TCD50 / cm3 accordance with chemotherapeutic index and 4. These compounds are considered highly promising and further research on animals. Other heterocyclic compounds have less pronounced antiviral properties. The results of experiments the compound 056, 20 963, 1411 recommended for further studies both in vitro and in vivo to develop on the basis of antiviral drugs. Keywords: nitrogen-containing heterocyclic compounds in rows of symmetrical and asymmetrical triazine, antiviral activity, Porcine Teschovirus, the maximum allowable concentration, chemotherapeutic index. Product Description popup.authors Бова Тетяна Олександрывна Волкова Ізабела В'ячеславівна Дерев'янко Станіслав Васильович Дмитрук Оксана Олександрівна Решотько Леонід Миколайович Стрекалов Володимир Миколайович Шеремет Людмила Іванівна popup.nrat_date 2020-04-02 Close