Registration Number
0217U001653,
0115U005603
, R & D reports
Title
Formation of complexes drugs with ligands and low molecular weight RNA and their therapeutic effectiveness
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Head
Tkachuk Zenoviy Yuriyovich,
Registration Date
14-03-2017
Organization
Institute of Molecular Biology and Genetics of NASU
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Spatial structures of complexes of D-mannitol with oligoribonucleotides and oligodeoxyribonucleotide were developed by the computer simulation method. It was found and analyzed binding energy of nitrogen bases and D-mannitol, the distance between them and atoms or groups that take part in interaction of these compounds. By FT-IR and Raman spectroscopy methods was shown that RNA and D-mannitol formatted complex whereas RNA and sorbitol or lactose didn't form such complex. Using pyrolytic mass spectrometry method was studied pyrolysis products for to find possible bonds between RNA and D-mannitol. So, the obtained data are indicated that there is more stable and compact RNA structure in complex RNA and D-mannitol.
Product Description
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Козлов Олександр Вадимович
Левченко Світлана Миколаївна
Рибенчук Аліна Олександрівна
Семерникова Лариса Іванівна
Скоробогатов Олександр Юрійович
Ткачук Валентина Василівна
Ткачук Зеновій Юрійович
Ткачук Лариса Володимирівна
Шайдюк Євген Олександрович
Шаповал Світлана Олександрівна
Яковенко Тетяна Григорівна
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2020-04-02
