Registration Number
0217U002668,
0114U000784
, R & D reports
Title
Development of strategies for using epigenetic mechanisms of prevention and treatment of diseases associated with systemic inflammation.
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Head
Kaidashev Igor Petrovich,
Registration Date
29-06-2017
Organization
Ukrainian Medical Stomatological Academy
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The latest concept of epigenetic control of chronic systemic inflammation, implemented by the comprehensive interaction of genetic factors and leading epigenetic factors, mediated by the presence of polymorphic variants of genes and changes in expression level of structural and signaling proteins, components of enzyme systems, effector molecules and receptors of signaling cascades of nuclear transcription factor kappa B and the main signaling systems has been developed. The connection between the carriership of allele 12Ala of Pro12Ala polymorphism of gene PPAR-gamma with the severe course of asthma against the background of coronary heart disease has been determined. In young people under conditions of positive energy balance, the formation of insulin resistance, signs of chronic systemic inflammation, changes in the level of central mechanisms of regulation of energy metabolism have been identified; the effectiveness of physiological correction of caloric intake restriction and increased physical activity has been proven. The leading role of leptin in the development of insulin resistance and inflammatory manifestations in pregnant women with obesity of II degree has been determined, and the relationship between the frequency of complications of preeclampsia, placental dysfunction and the degree of leptin increase has been established. In patients with psoriasis, the relationship between the severity of psoriasis and severity of metabolic disorders and systemic inflammation has been determined. Positive effect of resveratrol on etiopathogenetical mechanisms of the disease, the level of systemic inflammation and improvement of the clinical course of stable ischemic heart disease has been detected. Clinical efficacy of pioglitazone in the treatment of coronary heart disease against the background of chronic systemic inflammation and asthma concurrent with coronary heart disease has been substantiated. The inhibitory effect of 2-oxodolin-3-glyoxylic acid on the neurotransmitter imbalance in chronic moderate stress and neurosis has been proven.
Product Description
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Ємченко Яна Олександрівна
Ізмайлова Ольга Віталіївна
Баранова Алла Федорівна
Белан Оксана Василівна
Весніна Людмила Едуардівна
Коровіна Лідія Дмитрівна
Луценко Роман Вікторович
Мамонтова Тетяна Василівна
Микитюк Марина Володимирівна
Недоборенко Вадим Михайлович
Попова Ірина Борисівна
Савченко Леся Володимирівна
Сидоренко Антоніна Григорівна
Скочко Ольга Вікторівна
Тарасенко Костянтин Володимирович
Чекаліна Наталія Ігоревна
Черкун Олексій Юрійович
Шаєнко Златослава Олексіївна
Шевченко Юлія Сергіївна
Шликова Оксана Анатоліївна
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2020-04-02
