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Information × Registration Number 0219U001259, 0117U000021 , R & D reports Title Obtaining of biologically active compounds and monomers based on the principles of supramolecular catalysis and "green" chemistry popup.stage_title Head Popov Anatoliy Fedorovich, Доктор хімічних наук Registration Date 22-01-2019 Organization LM.Litvinenko Institute of Physical Organic and Coal Chemistry popup.description2 As a result of the performed researches, a general approach are proposed for the synthesis of condensed benzofuro, benzothieno, isomeric thienothieno [2,3-c] pyridine-3-one, based on the acylation of the corresponding heteroarylacetic acids and their derivatives of aliphatic anhydrides in the presence of Lewis acids. The obtained heterocondensed derivatives of pyrones and pyrilium are converted into heterylpyridines by the action of primary amines. The synthetic limits of these reactions have been investigated using a wide range of reagents (aliphatic anhydrides and primary amines), optimal conditions for conducting reactions have been selected, allowing for a wide variety of substitutions. The cyclic condensation of substituted 3-amino-1H-pyrazoles and asymmetric 1,3-dicarbonyl compounds has been studied. It is shown that the reaction direction depends on the steric and electronic effects of the substituents R1 and R2 and is regulated by the acidity of the medium. A regionelectovite method of synthesis of 7- (difluoromethyl) - and 5- (difluoromethyl) pyrazolo [1,5-a] pyrimidines was developed. The structural modification of benzofuro-, benzothieno-indolopyrimidines was carried out. Product Description popup.authors Аніщенко Ганна Володимирівна Богза Сергій Леонідович Редько Андрій Миколайович Рибаченко Володимир Іванович Смирнова Ольга Володимирівна Толкунов Андрій Сергійович Толкунов Валерій Сергійович Толкунов Сергій Володимирович Хижан Олександр Іванович popup.nrat_date 2020-04-02 Close