Search academic texts

Information × Registration Number 0220U001221, 0117U001018 , R & D reports Title To develop measures for the prophylaxys of relapce of MDR TB popup.stage_title Head Olena Tkach, Registration Date 24-02-2020 Organization Danylo Halytsky Lviv National Medical University popup.description2 Object - patients with drug-resistant pulmonary tuberculosis, medical history, statistical reporting. Methods - epidemiological, clinical, bacteriological, biochemical, immunological, sociological, statistical, analytical. Purpose - To reduce the rate of relapse of drug-resistant tuberculosis by improving the case management algorithm. Over the last 5 years, the overall tuberculosis structure has increased 2.9 times the recurrence rate due to an increase of 1.5 times the expanded and 2.0 times increased multidrug resistance of MBT with the prevalence of disseminated forms (54.2%) in men (80.0%) ) of productive working age (66.7%). Patients with infiltrative tuberculosis had the highest proportion of recurrence (55.4%), and the lowest in tuberculous pleurisy - 13.4%. The combination of 4 or more aggravating factors in 58% of patients increases the risk of relapse, low adherence to treatment - additional criteria for the formation of groups at increased risk of relapse are suggested. The scale of prognostic-admissible limits of parameters of individual biochemical, immunological indices, hematological indices made it possible to develop an algorithm of patient-oriented correction of treatment in case of DR-TB with differentiated use of innovative technologies of drug and non-drug treatment. cases that have been reflected in guidelines, patents, and informals. The study of the effectiveness of new chemotherapy regimens using bedaquiline and linezolid determines the feasibility of further studies to improve the individual approach to managing DR-TB. Product Description popup.authors Лаповець Наталія Євгенівна Мажак Квітослава Деонізівна Писаренко Євген Іванович Щурко Галина Василівна popup.nrat_date 2020-07-03 Close