Registration Number
0220U100483,
0118U003209
, R & D reports
Title
To develop new technologies of metabolic therapy based on epigenetic characteristics of tumors in patients with cancer of the gastrointestinal tract
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Head
Красносельський М.В.,
Registration Date
20-01-2020
Organization
Grigoriev Institute for medical Radiology NAMS of Ukraine
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Object of the study: combined treatment of the gastrointestinal cancer, metabolic disorders, epigenetic characteristics. The aim of the work: is to increase the effectiveness of treatment of patients with gastrointestinal cancers by individualizing metabolic therapy in the framework of combined treatment considering epigenetic disturbances. Research methods and apparatus: clinical, biochemical, statistical, chromatographic, PCR, biochemicalanalyzer Respons 910, Ultimate 3000 liquid chromatograph. Theoretical and practical results: Metabolic disorders in patients with colorectal and gastric cancer were evaluated before surgical removal of the tumor and on the 14th day after surgery. It was found that most metabolic parameters changed significantly after surgery in compare to initial values. Multicorrelation relationship parameters of carbohydrate, lipid and aminoacid metabolism before and after surgery showed a significant difference between colorectal and gastric cancer patients. There were several typical "metabolic patterns" that characterize certain changes in the carbohydrate, lipid and aminoacidscontents in blood serum that showedstrond specificity on the tumor location: Colorectal or gastric. Seven parameters appeared to be the most informative: Arginine, glutamine, leucine, valine, phenylalanine, asparagine, tyrosine. Novelty: New data on metabolic disorders in patients with colorectal and gastric cancer at various stages of combinative treatment. Implementation efficiency: none. Field of application - medicine, oncology.
Product Description
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Verbytskyi Maksym V.
Holubieva Larysa V.
Hranovska Hanna I.
Krasnoselskyi Mykola V.
Krutko Yevhen M.
Kulshyn Volodymyr Ye.
Lanko Liliia H.
Movchan Oleksii V.
Molodan Liudmyla Volodymyrivna
Muzhychuk Ivan V.
Nemaltsova Kateryna V.
Pidlisnyi Ruslan A.
Pavlichenko Yuliana V.
Perepadia Oksana V.
Popovska Tetiana M.
Radchenko Oleksandr A.
Revenkova Svitlana I.
Svynarenko Andrii V.
Slobodianiuk Olha V.
Khramtsov Roman Ye.
Cherkasko Liudmyla V.
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2020-04-02
