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Information × Registration Number 0220U101422, 0117U004977 , R & D reports Title To assess the impact of disfunctional adipose tissue on tumor microenvironment as well metastatic potential in overweight patients with gastro-intestinal cancers popup.stage_title Head Ганусевич Ірина Іванівна, Registration Date 11-02-2020 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  Disturbances of oxidative phosphorylation, increase of the rate of generation superoxidic radicals and guanine oxidation in DNA, gelatinases activities and worsening state of hypoxia in adipose tissue adjacent to the tumor, high content of fatty acids in blood in patients with obesity are connected with corresponding characteristics of redox state and density of cancer-associated adipocytes in tumor that determine tumor aggressive phenotype and are the important factors of RC progression. Obtained data may be as a promising prognostic factors of disease outcome in the treatment of patients with gastriointestinal cancer and overweight. Product Description popup.authors Bubnovskaya Larysa M. Burlaka Anatoliy P. Virko Sergij V. Vyskirko Sergii I. Vovk Anastasiya V. Galieieva Anastasiia M. Ganusevych Iryna I. Chernobai Vitalii A. popup.nrat_date 2020-04-02 Close