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Information × Registration Number 0221U106855, 0120U105184 , R & D reports Title Experimental study of the effectiveness and safety of new phytochemicals and bacterial preparations for the treatment of coronavirus and other common infections popup.stage_title Head Zadorozhna Viktoriia I., Доктор медичних наук Registration Date 21-12-2021 Organization State Institution "LV Gromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine" popup.description2  During the work, the identification and quantification of biologically active substances (BAS) of plant origin in medicinal plant raw materials by chromatographic and spectrophotometric methods were performed. Also, the original phytopharmaceutical composition "Lalosopil" was developed from medicinal plant raw materials, which on the basis of phytochemical analysis is promising in terms of antiviral activity, its analytical standardization and development of quality control methods. For the first time, the antiviral activity of the phytopreparation Lalosopil against herpes viruses type 1 and 2, surrogate hepatitis C virus - bovine viral diarrhea virus, coronavirus - transmissible porcine gastroenteritis (CBT) was shown. According to the high selectivity index, the phytopreparation Lalosopil in relation to herpes viruses, hepatitis C and coronavirus THC can be attributed to highly effective antiviral drugs. It is proved that the effect of the drug on the model of genital herpes in males in vivo, using a combined scheme of administration (per os and application), the index of effective therapeutic effect was at the level of the reference drug Virolex. Lalosopil is a polytarget drug, the mechanism of antiviral action of which is carried out at the level of inhibition of RNA and DNA synthesis and induction of α-interferon at the level of the reference inducer of interferon Poly (I) · Poly (C). Product Description popup.authors Bespalova Olena Yaroslavivna Holub Natalsya Borysivna Gorshunov Yurii V. Deriabin Oleh M. Lutsenko Tetiana M. Liulchuk Mariia H. Motronenko Valentyna V. Rybalko Svitlana L Shcherbinska Alla M popup.nrat_date 2021-12-21 Close