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Information × Registration Number 0222U000001, 0121U113511 , R & D reports Title Development of bioassay-biomarker battery for the evaluation of pharmaceutical-impacted aqueous environment popup.stage_title Head Stoliar Oksana B., д.б.н. Registration Date 01-01-2022 Organization Ternopil National Pedagogical University named after Volodymyr Hnatyuk popup.description2 The obtained results confirm the correctness of using the set of biomarkers of stress and cytotoxicity, selected in the first year of the project, and the development of this approach on the sensitivity of zinc metabolism to the effects of pharmaceuticals under combined exposure. The modulating effect of microplastics on the biological activity of ibuprofen was revealed in both populations. The generalization of the results of the study indicates special reactions of the organism to pharmaceuticals, opposite responses to typical xenobitics: this is an increase in lysosomal stability and activation of cholinesterase, which has analogs in higher vertebrates. Using the Integrated Biomarker Response Index, it was proved that the influence of the history of the population (eco-exposome) on the body's response to the damaging effect is decisive in comparison with the nature of the xenobiotic. In an ex vivo experiment using a model and hypothetical zinc chelators (TPEN and glyphosate), the dependence of the functional activity of metallothioneins on the mobility of zinc in cells was proved. An ex vivo model is recommended for assessing the acute toxicity of xenobiotics. Product Description popup.authors Baranovskyi Vitaliy S. Gladyuk Mykola M. Gnatyshyna Lesya L. Mischuk Natalia Yo. Martynyuk Victoriya V. Khoma Vira V. popup.nrat_date 2022-03-09 Close