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Information × Registration Number 0222U000639, 0121U100287 , R & D reports Title To Improve prevention of the occurrence of inhibitor in hemophilia patients by creating a prognostic model, based on the study of risk factors popup.stage_title Head Novak Vasyl L., Доктор медичних наукStasyshyn Oleksandra V., Доктор медичних наук Registration Date 14-01-2022 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description2 The object - 652 patients with hemophilia A and B aged 1 to 75 years, who were examined and treated in the SI IBPTM NAMS. The aim - based on the study of risk factors, to develop an adequate, convenient for use in practical medicine model in order to predict and prevent the occurrence of the inhibitor in patients with hemophilia. Methods - clinical, cytological, hematological, biochemical and coagulological. Criteria for treatment effectiveness: ABR, ABRs, ABRj. Discretionary regression models were used to substantiate the study of the relationship between different risk factors and the likelihood of inhibitor development. In patients with hemophilia, previously treated with plasma drugs of different degrees of purification, in the transition to treatment with modified recombinant drugs neutralizing inhibitors to FVIII (IX) do not occur. Prophylactic treatment significantly significantly reduced the annual bleeding rating of both ABR and AsBR and AjBR compared to patients receiving on-demand drugs, regardless of dose. The use of whole blood and FFP as the first drug significantly increases the risk of developing the inhibitor. The use of cryoprecipitate as the first drug does not affect the risk of inhibitor development. The highest frequency of inhibitor development was found in patients with retroperitoneal hematomas (58,5%), CNS hemorrhages (40%), subcutaneous and muscle hemorrhages (37,5%). Large surgical interventions significantly increase the risk of developing the inhibitor. The set of "external" predictors of inhibitor occurrence in patients with hemophilia was identified by the method of multiple logit regressions and their significance was assessed. Such predictors include: the amount of ED administered per 1 episode of bleeding, changes in the drug during treatment, the degree of purification, the presence of purulent complications, the size and type of surgery. According to the research, 1 innovation and 1 information letter were issued. Product Description popup.authors Dzis Roman P. Krasivska Valeriia V Serafyn Yuriy Y. popup.nrat_date 2022-03-09 Close