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Information × Registration Number 0222U000691, 0119U002252 , R & D reports Title Sulfurfunctionalized carboxy- and heterocyclic systems with anti-platelet and antioxidant activities as new promising substances for treatment of arterial thrombosis popup.stage_title Head Novikov Volodymyr P., Доктор хімічних наук Registration Date 14-01-2022 Organization Lviv Polytechnic National University popup.description2 A convenient one-pot approach to the synthesis of new sulfide derivatives of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracenyl) acetamides by the reaction of the corresponding 2-chloroacetamides of 9,10-anthracenedione with a number of alkyl (aryl/hetaryl) in the presence of potassium carbonate in DMF. Approaches to the preparation of water-soluble forms of sulfuric derivatives of carbocyclic and heterocyclic systems have been developed. A water-soluble form has been obtained for a promising dithiocarbamate derivative with the retention of its antioxidant and antiplatelet action in the micellar system. A laboratory procedure has been developed for the preparation of piperidine 3-chloro-9,10-anthraquinone as a promising compound with antiplatelet and antioxidant action. In vitro and in vivo studies of the antioxidant and antiplatelet action for thiosulfonate and quinoid derivatives have been carried out, and promising objects have been identified. The analysis of the pharmaceutical market of antithrombotic agents in Ukraine, as well as drugs - derivatives of 9,10-anthraquinone was carried out. Product Description popup.authors Iskiv Oksana P. Zaichenko Oleksandr S. Zvarych Viktor I. Karkhut Andrii I. Komarovska-Porokhnyavets Olena Z. Lubenets Vira I. Marintsova Nayaliya H. Monka Nataliya Ya. Moskalenko Nataliya I. Polish Nataliia V. Stasevych Maryna V. Fizer Luybov V. Fedorova Olena V. Chervetsova Veronika H. Shyian Galyna B. popup.nrat_date 2022-03-09 Close