Registration Number
0222U000961,
0118U100243
, R & D reports
Title
To study the age-depend peculiarities go molsidomine and ATP combination: physiological and pharmacy-toxicological studies
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Head
Bezrukov Vladyslav V, Доктор медичних наук
Registration Date
22-01-2022
Organization
State institution "D. F. Chebotarev Institute of Gerontology National Academy of Medical Sciences of Ukraine"
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Object - Balb / c laboratory mice and Wistar rats of two age groups (young - 7-8 months, old - 26 months); pharmacological combination of molsidomine with ATP (in the form of ATP-long - various ligand coordination compounds). The aim of the work is to study the pharmacological activity, general toxic properties, age-specific features of the combination of molsidomine with ATP and experimental substantiation of the development of a new drug for use in geriatrics. Models: ischemia-reperfusion (in an isolated heart of rats), chronic mild stress in young and old rats. Methods: physiological, pharmacological, morphological, immunological, biochemical. Main results: It was found that the combination of molsidomine with ATP showed a synergistic vasodilatory effect and clinically significantly enhanced the contractile function of the isolated heart of old rats, preventing its violation in hypoxia and reperfusion. In chronic stress, the drug had a positive effect on the central and local stress-limiting systems of the body, namely, contributed to the normalization of bioelectrical activity of the heart, prevented CNS dysfunction and stress-sensitive immune system, reduced peroxidation products in animals. With long-term administration in a wide range of doses, the combination did not show toxic effects on animals. The results of experimental studies indicate pharmacological (cardiotropic, neurotropic, antistress) activity and safety of the combination of molsidomine with ATP. The obtained data substantiate the practical application of the tool in geriatrics for the complex treatment of pathology of the cardiovascular and central nervous systems, as well as for post-stress rehabilitation of people who have suffered from chronic stress. The results of the work are presented in the form of a report, as well as presented in 7 articles and monographs.
Product Description
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Gudarenko Svitlana O
Kuprash Liana Petrivna
Labunets Iryna F
Panteleimonova Tetyana M
Sikalo Nina V
Sharabura Lyudmila B
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2022-03-09
