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Information × Registration Number 0222U001113, 0121U107497 , R & D reports Title Analytical approaches and methodological explanation for studying the biopharmaceutical equivalence of generic drugs in comparative tests in vitro popup.stage_title Head Yegorova Alla V., Доктор хімічних наук Registration Date 24-01-2022 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description2  The object of study - generic drugs PENTALGIN IС®, tablets and "MEMATON IC, film-coated tablets, 10 mg" (manufacturer - SLC "INTERCHEM"). The subject of the study - HPLC methods for the quantification of paracetamol, codeine, caffeine, metamizole sodium and phenobarbital to study the dissolution profiles of PENTALGIN IC®, tablets, taking into account the decomposition of metamizole sodium in aqueous solutions, and memantine hydrochloride to study the dissolution profiles of the drug MEMATON IC, film-coated tablets, 10 mg. Research methods - molecular absorption spectroscopy, high performance liquid chromatography (HPLC) with UV and mass detector. The main idea of the work was to develop and validate HPLC methods for quantification of released active pharmaceutical ingredients (API), to establish the biopharmaceutical equivalence of a number of domestic and foreign generic drugs in comparative in vitro tests (study of dissolution profiles). Product Description popup.authors Yegorova Alla V. Aleksandrova Daria I. Leonenko Inna I. Scrypynets Yulia V. popup.nrat_date 2022-03-09 Close