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Information × Registration Number 0222U001203, 0119U001085 , R & D reports Title Investigation of the frequency of BRAFV600E mutations in radiogenic and sporadic papillary thyroid carcinomas depending on the patients age at the time of surgery popup.stage_title Head Kravchenko Viktor Ivanovych;, д.мед.н.Tronko Mykola D, д.мед.н. Registration Date 24-01-2022 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description2  Object: incidence of thyroid cancer, histopathological characteristics of papillary thyroid carcinoma (PTC), BRAFV600E mutations in PTC. Objective: To continue monitoring the incidence of thyroid cancer in children and adolescents of Ukraine affected by the Chornobyl fallouts, to compare the frequency of BRAFV600E mutations, invasive properties and postoperative follow-up in radiogenic and sporadic PTC, as well as in BRAFV600E-positive and BRAF-negative patients of different ages. Methods: morphological, immunohistochemical, statistical. Theoretical and practical results: The incidence of thyroid cancer per 100 thousand relevant population in high-risk groups (children and adolescents at the time of the Chornobyl accident), both in Ukraine as a whole and in the six most affected northern regions was characterized by increasing time-trends for the period from 1990 to 2020. The difference between the indicators in the least and most affected regions persisted until 2020, which may indicate the presence of an additional radiogenic component of the disease in the contaminated regions of Ukraine for 34 years. The BRAFV600E mutation was more common in sporadic than radiogenic papillary thyroid carcinomas (PTCs), but the presence of such a mutation is not associated with higher tumor aggressiveness and worse prognosis in patients aged up to 28 years at the time of surgery, regardless of PTC's etiology. Product Description popup.authors Bohdanova Tetiana I. Bolgov Myhailo Yuriyovych Burko Svitlana Valentynivna Gulevatyi Sergiy Vasyliovych Degtiariova Tetiana Leonidivna Zurnadzhy Ludmyla Yliivna Tereschenko Valery Platonovych Tron`ko Мykola Dmytrovych Chernyshov Sergiy Viktorovych Shpak Viktor Myhailovych popup.nrat_date 2022-03-09 Close