Registration Number
0222U001432,
0116U007973
, R & D reports
Title
Influence of humoral factors on the mechanisms of development of pathological processes in the liver under the action of exogenous and endogenous factors and under their correction
popup.stage_title
Head
Рикало Надія Анатоліївна,
Registration Date
27-01-2022
Organization
Vinnytsia National Pirogov Memorial Medical University
popup.description2
Biochemical and morphological studies have established dose-dependent effects of 40% ethanol, determined lethal (25ml / kg) and sublethal doses (20ml/kg) 40% ethanol on the body of laboratory rats. Significant changes in biochemical markers of cholestasis and hepatocyte cytolysis syndromes were revealed. Changes in the protein-synthesizing function of the liver and changes in pigment metabolism have been recorded. Morphological changes in the liver in experimental simulations of acute alcoholic hepatitis in rats indicate the presence of fatty degeneration of the liver studied by administering to rats 40%. It has been reliably established that Corvitin as a mono- or complex therapy with Glutargin has a pronounced corrective effect on the processes of oxidative stress. At the same time, the results of the study indicate slightly pronounced antioxidant properties of "Glutargin" when used as monotherapy.
In chronic toxic hepatitis (CTH) and with medication correction, we found that the use of lisinopril in rats normalizes the level of serum IGF-1. In rats, with the introduction of lisinopril, a significant decrease in the percentage of hepatocyte nuclei with a subdiploid DNA set was established by 1.5 times compared with such an indicator with CTH. It was found that with the introduction of L-arginine L-glutamate in the liver tissue, the percentage of fragmented nuclei with a sub-diploid DNA set increases, the combined use of Lisinopril and L-arginine L-glutamate reduces the percentage of fragmented nuclei in the liver tissue. According to the results of a study of morphological changes in rat tissue with CTH and its drug correction, it was found that against the background of the introduction of Glutargin, stabilization and restoration of the organization of hepatocytes is observed.
Product Description
popup.authors
Ivanitsa Arina Olexandrivna
Baylo Oksana Viktorivna
Bereznyak Mykhailo Andriyovych
Grushko Tetyana Anatoliyivna
Movchan Tetyana Leonidivna
Mordvinova Olena Mikhailivna
Olyynik Julia Mykhaylivna
Piliponova Victoriia Volodymyrivna
Romanenko Irina Volodymyrivna
Semenchuk Svitlana A.
popup.nrat_date
2022-03-09
