Registration Number
0222U002319,
0119U101624
, R & D reports
Title
Synthesis, spectral-luminescent properties of new alkylamino-beta-ketoenol compounds and metal complexes based on them to produce fluorescent probes of biomolecules and optical materials
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Head
Pekhno Vasyl I., Доктор хімічних наук
Registration Date
11-02-2022
Organization
Institute of General and Inorganic Chemistry. VI Vernadsky National Academy of Sciences of Ukraine
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Condensed derivatives of dehydroacetic acid with crotonaldehyde and benzaldehyde and phthalocyanine complexes of zirconium and hafnium based on them have been synthesized. The effect of Zr phthalocyanine complexes with dehydroacetic acid and its condensed derivatives with crotonaldehyde and benzaldehyde on insulin fibrillation was studied by analysis of amyloid-sensitive fluorescent dye, scanning electron microscopy, fluorescence spectroscopy, UV-Vis spectroscopy. It is shown that the presence of Zr phthalocyanines modifies the process of fibril formation. Monitoring of insulin fibrillization kinetics showed that the presence of phthalocyanines reduces the intensity of this reaction by 45-68% of the initial intensity.
Product Description
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Anisimova Alina M
Losytsʹkyy Mykhaylo Yu.
Selin Roman O
Tretyakova Iryna M
Fedosova Natalia M
Chernii Viktor Yaroslavovych
Chernii Svitlana V.
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2022-03-09
