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Information × Registration Number 0222U003470, 0119U100331 , R & D reports Title Newest hybrid anti-tumor and anti-inflammatory nanocomplexes based on pyrrole and C60-fullerene: creation, characterization, pharmacodynamics and toxicological characteristics. popup.stage_title Head Rybalchenko Volodymyr K., Доктор біологічних наук Registration Date 29-03-2022 Organization Taras Shevchenko National University of Kyiv popup.description2 Object of study: 3 - {[4-chloro-1- (4-chlorobenzyl) -2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl] amino} phenyl [6,6] - phenyl-C61-butanoate (C60-MI-3OH) in combination with cold-pressed linseed oil. Subject of research: pharmacological activity, pharmacodynamicananocomplex during the development of inflammatory bowel disease and colorectal cancer. The aim of the work is to establish anti-inflammatory and antitumor efficacy, pharmacodynamics C60-MI-3OH for the correction of inflammatory diseases of the colon and related pathologies. Research methods: chemical synthesis, mathematical modeling histological, biochemical, hematological, cultural, statistical analysis. It has been shown that the C60-MI-3OH nanocomplex is able to form stable bonds with the ATP-binding site of EGFR and VEGFR growth factors, which may be one of the mechanisms of its biological action. C60-MI-3-OH has anti-inflammatory properties against acute inflammation of the colon, anti-tumor properties against its DMG-induced cancer, is able to partially restore impaired liver function under these conditions and prooxidant-antioxidant state of the colon, but negatively affects the skin. In this case, with increasing duration of exposure and decreasing dose of the compound, the negative effects increase.  Product Description popup.authors Bielinska Iryna V. Hovorun Dmytro М. Hurmach Vasyl V. Dzyubenko Natalia V. Kuznezova Galyna M. Lynchak Oksana V. Lozovskyi Valerii Z. Milokhov Demyd S. Nyporko Oleksii Yu. Prylutska Svitlana V. Prylutskyy Yuriy І. Repetsky Stanislav P. Rusinchuk Natalia M. Stoika Rostyslav S. Khilya Olga V. Zyvinska Svitlana M. Chereschyuk Iryna O. popup.nrat_date 2022-03-29 Close