Search academic texts

Information × Registration Number 0222U005043, 0118U000103 , R & D reports Title Study of new biochemical, molecular genetic, biophysical and clinical mechanisms of eye diseases and development of new methods of prevention, treatment and prediction of eye diseases popup.stage_title Head Hudz Andrii Stepanovych, Доктор медичних наук Registration Date 13-12-2022 Organization Danylo Halytsky Lviv National Medical University popup.description2  it has been proven that neopterin is a marker of activation of cellular immunity in various pathologies of the body; it was determined that apoptosis of lymphocytes can contribute to the resolution of uveitis; it was proved that an increase in the frequency of heterozygote G/A polymorphism rs759853 accompanied the development of T2DM without retinopathy; an increase in the frequency of A/A mutant homozygotes accompanied the development of DR, and to a greater extent – ​​its proliferative variant; with increasing severity of the pathological process and progression of DR, a clear pattern is noted - an increase in the frequency of the ancestral allele G and a decrease in the frequency of the mutant allele A of the rs9640883 polymorphism of the AKR1B1 gene; the proven effect of the rs2010963 polymorphism on the level of VEGFA in VOR and the relationship with gender, the presence of DPR and neovascularization of the DZN; for the rs699947 polymorphism, the influence of the genotype on MGZK, TTS, the level of VEGFA in the VOR, the presence of DPR and hemophthalmos was proven; it was established that with experimental hypothyroidism, the level of lipid peroxidation products in the tissues of the conjunctiva and cornea increases; it was found that with hypothyroidism, the concentration of malondialdehyde in the tear fluid increases by 1.5 times - in the initial stage and by 1.65 times - in the severe stage of hypothyroidism. Докладніше про цей текст оригіналуЩоб дізнатися більше про переклад, введіть текст оригіналу Надіслати відгук Бічні панелі Product Description popup.authors Blavatska Oksana Mykolaiivna Bushuyeva Oksana Valeriivna Zakharevych Galyna Evgenivna Kuryltsiv Nadiya Bagrationivna Maksymtsiv Myroslava Liubomyrivna Novytskyi Ihor Ya Pavlovska Halyna Yaroslavivna Sydorchuk Uliana Petrivna Shchur Marta Bohdanivna Yurevych Vsevolod Romanovych popup.nrat_date 2022-12-13 Close