Search academic texts

Information × Registration Number 0223U000680, 0119U103778 , R & D reports Title To improve the system of medical support for boys with delayed sexual development, taking into account the degree of hypoandrogenism and comorbid diseases. popup.stage_title Head Tupchyna Svitlana I., Доктор медичних наук Registration Date 18-01-2023 Organization State institution "Institute for the Protection of Children and Adolescents of the National Academy of Medical Sciences of Ukraine" popup.description2 Object: physical and sexual development, the state of somatic health, hereditary burden, hormonal, metabolic and immunological disorders, the state of free radical oxidation and antioxidant protection in adolescents from 14 to 17 years old with signs of androgen deficiency (delayed sexual development). Objective: increasing the efficiency of treatment for boys with hypoandrogenia by developing a prognosis of the course of the delayed sexual development and formation of comorbid conditions, personification of approaches to examination and therapy. Methods: clinical, genetic, biochemical, enzyme immunoassay instrumental, radiological. Results: Significant factors influencing the progression of HA and the formation of comorbid pathology in androgen deficiency in boys with DSD were identified. The most informative signs are combined into separate prognostic tables regarding the unfavorable course of HA, the formation of pathology of the cardiovascular and hepatobiliary pathologies. Novelty: for the first time the mechanisms of progression of androgen deficiency in adolescents with DSD were studied, the relationship between the degree of HA and the violation of the functional state of the cardiovascular and hepatobiliary systems was proved, which is the basis for involving specialists from a multidisciplinary team in the examination and treatment of adolescents with HA. The developed forecasting technology makes it possible with a high probability to determine the risk group for the progression of androgen deficiency and somatic health disorders in boys with DSD. Efficacy: determination of an individual prognosis regarding the course of HA will allow the appointment of personalized preventive and therapeutic measures aimed at preventing and correcting hormonal and metabolic disorders in adolescents with an unfavorable prognosis for the course of HA, who have a high risk of developing comorbid pathology. This is the key to maintaining the reproductive potential and somati Product Description popup.authors popup.nrat_date 2023-01-18 Close