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Information × Registration Number 0223U000684, 0120U100153 , R & D reports Title Development of new ways of obtaining substituted benzothiazoles, benzoxazoles, oxazolopyridines, thiazolopyridines, imidazopyrimidines and modification of their structures by transformation of functional groups popup.stage_title Head Tolkunov Sergej V., Доктор хімічних наук Registration Date 18-01-2023 Organization Institute of Physical and Organic Chemistry and Coal Chemistry. LM Litvinenko of the National Academy of Sciences of Ukraine popup.description2  As a result of this research, a general approach to the synthesis of 2-mercapto-1,3-benzothiazoles was proposed, based on heterocyclization of o-halogenaniline derivatives with sodium xanthogenate or carbon disulfide in pyridine in the presence of organic bases - triethylamine, 1,4-diazobicyclo[2.2.2]octane. The synthetic limits of these reactions, depending on the reagents and reaction conditions, have been studied, which makes it possible to vary widely the substituents in the benzene cycle. A method of obtaining variously substituted 2-chloro-1,3-benzothiazoles by the action of chlorine on 2-mercapto-1,3-benzothiazoles in the two-phase chloroform-hydrochloric acid system was developed. The method gives high yields of 2-chloro-1,3-benzothiazoles and high product purity (90%). A new method of obtaining polysubstituted 2-bromo-1,3-benzothiazoles by the action of bromine on 2-mercapto-1,3-benzothiazoles in the two-phase system chloroform-water in the presence of tetrabutylammonium bromide was developed. A method of obtaining polysubstituted methyl 2-R1,R2-amino-1,3-benzothiazoles by nucleophilic substitution of chlorine in position 2 on the amino function was developed. Electrophilic substitution in 1,3-benzothiazoles was studied (nitration, sulfochlorination). It was shown that electrophilic substitution occurs at position-6 of the benzene ring of benzothiazole. Carbonylation of 2-chloro derivatives of benzothiazoles was studied. The possibility of selective synthesis of carboxymethyl derivatives of benzothiazole is shown. A large array of 1,3-benzothiazoles containing various substituents in all positions of 1,3-benzothiazoles, which can be used to create new medicinal products, has been synthesized. Product Description popup.authors Bohza Sergiy L. Smirnova Olga V. Tolkunov Andriy S. Khyzhan Oleksandr I. popup.nrat_date 2023-01-18 Close