Registration Number
0223U001169,
0119U103927
, R & D reports
Title
To investigate polymorphisms of collagen genes and vitamin D receptor gene of degenerative disc disease patients
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Head
Pedachenko Yevhenii H., Доктор медичних наук
Registration Date
25-01-2023
Organization
The State Institution Romodanov Neurosurgery Institute National Academy of Medical Sciences of Ukraine
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Реферат (англійською мовою): Gene polymorphisms were studied in patients with degenerative lesions of intervertebral discs C5-C7 (10 women, 20 men), L4-L5 (26 women, 30 men), L5-S1 (38 women, 30 men) aged (34.49 ± 6, 72) years) and 66 individuals of the comparison group (36 women and 30 men aged (35.00 ± 6.51) years. All polymorphic variants COL1A1rs1800012, COL2A1rs2276454, COL2A1rs1793953, COL9A1rs1135056, COL11A1rs16764862, VDR 7022 were detected in the study group and the comparison group. . Differences in the frequency of risk alleles of collagen gene and vitamin D receptor gene polymorphisms were revealed depending on the location of the affected intervertebral discs. Statistically significant associations of degenerative lesions of intervertebral discs and genetic variants COL1A1rs1800012, COL2A1rs2276454, COL9A1rs1135056, COL11A1rs1676486, VDR rs2228570 were revealed. The highest percentage of risk alleles of polymorphisms of all studied genes was observed in patients with degeneration of the intervertebral discs of the cervical spine and L5-S1. The obtained data should be verified in a further study on a larger number of patients.
Product Description
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Vasiliev Iryna Georgievna
Gallant Olena Stepanivna
DMYTRENKO Angela Borysivna
Makarova Tetyana Anatolyivna
OLEKSENKO Natalia Pavlivna
SLYNYKO Yevhenii Ihorovych
KHYZNYAK Mykhailo Vitaliyovych
TSYUBKO Olga Ivanivna
CHOPYK Natalia Hryhorivna
Shuba Iryna Mykolaivna
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2023-01-25
