Registration Number
0224U002781,
(0118U005470)
, R & D reports
Title
Investigation of functional plasticity of macrophages under the conditions of application of means of chemo- and biotherapy of cancer
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Оцінити доцільність використання досліджених показників стану моноцитів/макрофагів для прогнозу ефективності застосування імунотерапевтичних протипухлинних речовин в монорежимі, або в комбінації з хіміотерапією при різних за метастатичним потенціалом пухлинах.
Head
Fedosova Nataliia I., Кандидат біологічних наук
Registration Date
29-02-2024
Organization
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine
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In vivo studies on C57Bl (LLC model) and Balb/c (ACE model) mice showed antitumor/antimetastatic efficacy of B. subtilis IMV lectin B-7724 as a means of immunotherapy. The severity of the effect depended on the mode of administration (monomode, combination with chemotherapy) and the characteristics of the model tumor: for mice with ACE, lectin administration was more effective in monomode (tumor growth inhibition index, TGI =53.2%); with LLC - combined administration of lectin and cisplatin (TGI =76.5%, metastasis inhibition index, IIM=78.6%). The demonstrated effect in both cases is related to the lectin's ability to remodulate and maintain for a long time against the background of tumor growth the polarization of macrophages in the direction of the pro-inflammatory state M1. This is evidenced by the strong positive correlation found between the level of NO/Arg and indicators of tumor growth and metastasis. The obtained results indicate that the antitumor/antimetastatic effectiveness of the used chemo-/immunotherapy agents depends both on the immunogenic characteristics of the tumor and on the initial physiological features of the immune system. The expediency of using indicators characterizing the phenotype and functional properties of cells of the macrophage cell to evaluate the effectiveness of the therapy has been demonstrated.
Product Description
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Bazas Volodymyr M.
Berezhna Ninel M.
Voeykova Iryna M.
Didenko Hennadii V.
Karaman Olha M.
Kruts Olena O.
Symchych Tetiana V.
Cheremshenko Nadiia L.
Chumak Alina V.
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2024-02-29
