Registration Number
0225U001083,
(0120U102944)
, R & D reports
Title
Morphological and pathophysiological aspects of the influence of plastic components (Bisphenol A) on the development and functioning of organs and organ systems
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Клітинні, тканинні та функціональні зміни органів та систем органів, що викликані тривалим впливом Бісфенолу А.
Head
Silkina Yuliia V., Доктор медичних наук
Registration Date
24-01-2025
Organization
State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine"
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Study of the development and functioning of organs and organ systems under the influence of plastic components (Bisphenol A)
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On the basis of clinical, questionnaire, instrumental, functional, laboratory, microbiological and statistical methods of research, a complex of factors affecting pathological changes in spermatogenesis under long-term exposure to bisphenol A (BPA) was determined. The understanding of the destruction of the structural links of the spermatogenic epithelium and the violation of the hormonal status, which reduces the level of fertility, has been expanded. New data were obtained on the dynamics of changes in sperm parameters depending on the dose and duration of BPA exposure. A model of the unfolding of pathological changes in BPA-induced damage to the reproductive system has been developed, which allows predicting the development of negative changes in spermatogenesis. A model of the toxic effect of BPA was created, which contributes to the effective diagnosis of fertility disorders.
Product Description
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Bondarenko Mykola O.
Bondarenko Oleksandr O.
Yaroshenko Denys S.
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2025-01-24
