Search academic texts

Information × Registration Number 0225U001210, (0123U103260) , R & D reports Title To investigate the level of hemolysis in patients with indolent B-cell non-Hodgkin's lymphoma depending on the histomorphological structure and immunohistochemical variant of the tumor popup.stage_title Оцінити клініко-лабораторні особливості перебігу індолентної В-клітинної неходжкінської лімфоми у первинних хворих та хворих з рецидивами залежно від гістоморфологічної структури та імуногістохімічного варіанту пухлини. Head Sivkovych Svitlana O., Доктор медичних наук Registration Date 27-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 To investigate the activity of hemolytic processes in patients with indolent B-cell non-Hodgkin's lymphoma depending on the histomorphological structure and immunohistochemical variant of the tumor for the selection of treatment tactics. popup.description2  The object of the study is patients with indolent B-cell non-Hodgkin lymphoma (B-NHL) of varying degrees of aggressiveness, erythrocytes and blood serum of patients with indolent B-NHL. The aim of the work is to study the clinical, laboratory and immunological indicators of the hemolytic process in patients with indolent B-cell non-Hodgkin lymphoma depending on the degree of aggressiveness of the disease. Research methods are general clinical, immunohematological, biochemical, statistical. On the topic of the research, 19 patients with indolent B-NHL were examined. The age of the patients ranged from 37 to 78 years. The reference group sample included 28 venous blood samples from practically healthy individuals. A study of general clinical indicators, autoimmune antierythrocyte antibodies, and indicators of resistance of the erythrocyte cell membrane to osmotic destruction was conducted. In 100% of patients with indolent B-NHL, destructive changes in glycerophospholipids and impaired functional activity of the erythrocyte cell membrane were detected, which led to a decrease in the resistance of the erythrocyte membrane to osmotic destruction in 37% of patients. Activation of hemolysis in patients with indolent B-NHL (cold forms of autoimmune antierythrocyte antibodies, complementary type of autoimmune reaction, decreased resistance of the erythrocyte membrane to osmotic lysis) was accompanied by an aggressive course of the disease and required a change in treatment tactics. The threefold predominance of cold forms of autoimmune antierythrocyte antibodies over warm ones may reduce the effectiveness of therapy in patients with indolent B-NHL. Hypo- or normochromic anemia of varying severity was detected in 68.7% of primary patients, impaired protein-synthesizing liver function was observed in 25.0% of patients, and impaired functional activity of transaminases in 62.5%. Medical and social effect. Medicine Product Description popup.authors Bortnik Hanna A. Myronenko Halyna A. Serhutina Svitlana Yu. Tymoshenko Uliana V. popup.nrat_date 2025-01-27 Close