Registration Number
0226U001135,
(0123U101083)
, R & D reports
Title
Cellular and humoral mechanisms of neuroprotection in in vivo and in vitro models of brain damages
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Аналіз міжклітинних взаємодій у нормі та в умовах розвитку нейродегенеративних процесів
Head
Skybo Halyna H., Доктор медичних наук
Registration Date
21-01-2026
Organization
Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine
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Investigation of factors that have the neuroprotective potential in conditions of experimental brain damage simulation, and analysis of cellular and humoral mechanisms of neuroprotection
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Intercellular interactions in the nervous tissue of various parts of the nervous system were investigated in in vitro and in vivo model systems — both under normal conditions and during the development of neurodegeneration. The work considers new approaches to neuroprotection, in particular the use of probiotics and microbiota metabolites. The potential effectiveness of the probiotic strain Lactobacillus casei as an in vivo neuroprotective agent has been established. In vitro data confirm that lactobacterial metabolic products and sodium butyrate increase the resistance of nerve cells to OGD- and LPS-induced damage.
In the in vitro model, the ability of oligodendrocytes derived from human neuroepithelial stem cells to myelinate human neuronal axons after their transplantation into an organotypic culture of the cerebral cortex was demonstrated, indicating their functional integration and regenerative potential for restoring the recipient’s myelin structures.
In a hemiparkinsonism model, the spatial organization of rotenone-induced astrogliosis in the rat substantia nigra was analyzed. Immunohistochemical analysis showed that increased proliferative activity of astrocytes is localized in areas of degeneration of dopaminergic neurons, indicating close spatial and functional interactions between glial cells and neurons undergoing toxic damage.
Product Description
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Halyna H. Skybo
Tetiana M. Kovalenko
Iryna O. Osadchenko
Oleh M. Tsupykov
Iryna V. Lushnikova
Roman I. Koval
Maryna A. Patseva
Oleksandr G. Nikonenko
Kateryna H. Smozhanyk
Valeriia O. Zhovannyk
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2026-01-21
