Registration Number
0226U002403,
(0123U102367)
, R & D reports
Title
Features of genes expression that determine the development and formation of chemoradioresistance in myeloid neoplasms
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Аналіз експресії генів, що беруть участь у формуванні окиснювано-відновної системи (redox) в клітині (глутатіон, тіоредоксиН) та оцінка рівня експресії генів G-CSFR, C/EBP-α, SNAIL тощо під дією Vit E в культурах клітин K562.Визначити вплив тирозинкіназної активності онкобілка Bcr-Abl на активність та локалізацію USP1 у клітинах ХМЛ.
Head
Telehieiev Henadii D., Доктор біологічних наук
Registration Date
24-02-2026
Organization
Institute of Molecular Biology and Genetics of NAS of Ukraine
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The aim of the work is to study the factors that determine the onset, tumor progression and the formation of chemoradioresistance in patients with myeloproliferative human neoplasms (MPN) and in the development of diagnostic and possibly therapeutic approaches on this basis.
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A reverse correlation was demonstrated between the leukaemic stem cell phenotype of C562 blast cells with CML by vitamin E- and G-CSF-dependent inhibition of mRNA expression of the EMT transcription factor SNAIL, the pluripotent transcription factor OCT4, and LSCs (leukaemic stem cells) — the associated gene PLAP (placental-like alkaline phosphatase) and myeloid differentiation potential, by activation of mRNA expression of myeloid markers C/EBPα and TNAP genes, along with activation of E-cadherin gene expression in CML K562 blast cells in vitro. The differentiating potential of vitamin E in activating myelopoiesis factors in parallel with the action of G-CSF in the treatment of K562 blast cells of CML in vitro has been confirmed.
Product Description
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Olha V. Zimina
Mykhaylo V. Dybkov
Tetiana Y. Lysetska
Svitlana V. Antonenko
Ihor V. Kravchuk
Liudmyla P. Shvachko
Henadii D. Telehieiev
Dmytro S. Hurianov
Lev O. Polishchuk
I. O. Anykevych
O. M. Nikitina
N. V. Malyshok
A. Y. Shchaslyvyi
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2026-02-24
