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Information × Registration Number 0317U005006, 0116U005749 , R & D reports Title Testing and research ASIC1a antagonists in animal experimental models (code I.1 03. by the State Classification of Scientific and Technical Activities DK 015-97: "Research and development in the biological sciences") popup.stage_title Тестування та дослідження антагоністів ASIC1a на тваринних експериментальних моделях" (код І.1 03 за Державним класифікатором видів науково-технічної діяльності ДК 015-97: "Дослідження та розробки в галузі біологічних наук Head Maximyuk Oleksandr Petrovych, Registration Date 25-01-2017 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 As a result а model of antagonists of the ASIC channels was founded. Antagonists of the ASIC channels can act as an algesics new pharmacological agents. In addition, ASIC channels are molecular targets against ischemic brain injury, multiple sclerosis, epilepsy and other brain pathologies. At this time there is nos elective small molecules that can inhibit the activity of the ASIC channels, and thus creating new chemotype antagonists ASIC channels is an actual problem of modern pharmacology of pain and other ischemic injuries. Done electrophysiological and in vivo screening of 36 names of the antagonists of the ASIC1channels and the comparative analysis to determine optimum farmakofore. Research conducted by the method of "patch-clamp", which is the gold standard in pharmacology of ion channels.5481 Product Description popup.authors Єгорова Олена Володимирівна. Ісаєв Дмитро Сергійович Кришталь Олег Олександрович Максимюк Олександр Петрович popup.nrat_date 2020-04-02 Close