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0411U006233,
к.мед.н.
27-10-2011
o
Structure, growth and formation of the skeletal bones under effect of manganese enhanced hydroxyapatite implants into the tibia
Lubenets Aaleksandr Aleksandrovich,
popup.head Luzin Vladislav Igorevich
popup.opponent Савенко Людмила Данилівна
popup.opponent Кривецький Віктор Васильович
Дисертаційна робота присвячена вивченню морфогенезу кісток скелету статевозрілих білих щурів після імплантації до проксимальних відділів діафізів великогомілкових кісток біогенного гідроксилапатитного матеріалу ОК-015, насиченого марганцем в різних концентраціях. За допомогою комплексу сучасних морфологічних методів дослідження доведено, що імплантація гідроксилапатитного матеріалу ОК-015 супроводжується уповільненням темпів росту досліджуваних кісток, звуженням проксимальних епіфізних хрящей та шарів діафізів плечових кісток, зниженням вмісту первинної спонгіози і питомої щільності клітин в зоні остеогенезу, зменшенням діаметрів остеонів та збільшенням діаметрів їх каналів, гіпергідратацією і демінералізацією з пропорційним дисбалансом їх хімічного складу, дестабілізацією ультраструктури біомінералу кісток, а також зменшенням їх міцності. Доведено, що насичення імплантованого матеріалу ОК-015 марганцем значною мірою згладжує неблагоприємні зміни морфогенезу скелету при пластиці дефектів великогомілкових кісток; оптимальною концентрацією марганця в імплантаті є 0,25%.
2011-10-27
2020-04-04
Updated: 2025-12-08
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